The Macedonian Museum of Contemporary Art was established in 1979 by a group of visionary people who wanted to create an institution that would on the one hand promote Greek and international contemporary art by informing the public about art and aesthetics, and on the other publicise contemporary Greek cultural life abroad. These aims are achieved by organising solo, group, and retrospective exhibitions, round tables, and talks and by taking part in international programmes. This is a living museum, which follows cultural movement at an international level.

The museum loans works to other museums in Europe (such as the Kunsthalle in Bonn and the Jeu de paume in Paris); works with Greek visual arts institutions, such as the Lambrakis Foundation, the Benaki Museum, and the National Gallery; organises exhibitions of Greek and foreign artists often for the first time in Greece; publishes complete catalogues of its exhibitions; and liases closely with Aris Georgiou on the joint organisation of Photosynkyria, the international photography festival.

The museum shop sells all the publications connected with the group and solo exhibitions which the museum has organised (catalogues, posters, silk-screen prints, engravings, and postcards), a limited number of copies of small art objects bearing the signatures of such artists as Picasso, Modigliani, Pavlos, Akrithakis, Fasianos, Mytaras, and Varotsos, books on contemporary art (painting, sculpture, photography), monographs by Greek and foreign artists, and monographs on major movements of the 20th century.